Ku Ding Cha tea… want to lose those bulging fat cells…. Inhibit 12 lipoxygenase.

Abstract: We evaluated the inhibitory effect of 12 Chinese teas on leukocyte-type

12-lipoxygenase (LOX) activity. Tea catechins such as epigallocatechin gallate have been

known to exhibit leukocyte-type 12-LOX inhibition. Qing Shan Lu Shui, which contains

lower catechin levels than the other tested teas, suppressed leukocyte-type 12-LOX

activity. To characterize the bioactive components of Qing Shan Lu Shui, leukocyte-type

12-LOX inhibitory activity–guided fractionation of the aqueous ethanol extract of the tea

was performed, resulting in the isolation of two new monoterpene glycosides: liguroside A

(1) and B (2). The structures of compounds 1 and 2 were characterized as (2E,5E)-7-

hydroperoxy-3,7-dimethyl-2,5-octadienyl-O-(α-L-rhamnopyranosyl)-(1″→3′)-(4′″-O-trans￾p-coumaroyl)-β-D-glucopyranoside and (2E,5E)-7-hydroperoxy-3,7-dimethyl-2,5-octa-dienyl￾O-(α-L-rhamnopyranosyl)-(1″→3′)-(4′″-O-cis-p-coumaroyl)-β-D-glucopyranoside, respectively,