FAAH (fatty acid amide hydrolase) is an enzyme that plays an important role in the endocannabinoid system, which is involved in the regulation of pain, memory, and other cognitive functions. Research has shown that FAAH may be involved in the development of dementia, as FAAH inhibitors have been found to have protective effects against Alzheimer's disease and other forms of dementia [1]. For example, a study conducted in 2021 found that a dual inhibitor of MAGL and FAAH, JZL-195, was able to reduce the symptoms of Alzheimer's disease-like sporadic dementia in mice [2]. Additionally, a review published in 2021 found that FAAH inhibitors may be useful for the treatment of Alzheimer's disease and other forms of dementia due to their ability to affect learning and memory [3].
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